| Rank* | Name | Team | Position | Age** | ETA*** |
| 1 | David Price | | SP/RP | 23 | 2009 |
| Everyone's top pitching prospect. Will be something special for the Rays. |
| 2 | Michael Bowden | | SP | 22 | 2009 |
| Top Boston pitching prospect. Will make an impact in '09. |
| 3 | Tommy Hanson | | SP | 22 | 2009 |
| AFL MVP in 2008. Strikeout machine. Ready for the big time. |
| 4 | Chris Tillman | | SP | 21 | 2009 |
| Much-hyped pitcher. Lived up to the billing last season. Might have control issues early on. |
| 5 | James McDonald | | SP | 24 | 2009 |
| Strikeout artist primed for the big time. Keep your eye on him in spring training, |
| 6 | Jeff Samardzija | | RP | 24 | 2009 |
| Impressive numbers in major league debut. Will be a good 8th inning guy in '09. |
| 7 | Carlos Carrasco | | SP | 22 | 2009 |
| Exciting player who has been close to the majors. Solid winter league numbers going into the '09 season. |
| 8 | Scott Lewis | | SP | 25 | 2009 |
| Four wins in four starts as a big leaguer. Doesn't impress with his stuff but gets the job done. |
| 9 | Nick Adenhart | | SP | 22 | 2009 |
| Had a disastrous start to his big league career. Look for him to bounce back. |
| 10 | Trevor Cahill | | SP | 21 | 2009 |
| Played on the Olympic team and impressed. Could be a late season call-up in '09. Good K-rate with low HRs. |
| 11 | Daryl Thompson | | SP | 23 | 2009 |
| Well developed starter who should see significant time in the majors next season. |
| 12 | David Huff | Cleveland Indians | SP | 24 | 2009 |
| As ready as anyone. Should make the team out of spring. 143:29 K:BB ratio last season. |
| 13 | J.A. Happ | Philadelphia Phillies | SP | 26 | 2009 |
| Primed pitcher with solid stuff to anchor the Phillies' rotation. |
| 14 | Brett Anderson | Oakland Athletics | SP | 21 | 2009 |
| Improving his opponent's AVG. Great K:BB ratio throughout his career. |
| 15 | Derek Holland | | SP | 22 | 2009 |
| Quick climb through the Rangers' organization. Spectacular numbers in AA with a 0.69 ERA in 4 starts. |
| 16 | Wade Davis | Tampa Bay Rays | SP | 23 | 2009 |
| Well-developed, ready for the big leagues. Needs room to clear in the Rays rotation. |
| 17 | Jeff Niemann | Tampa Bay Rays | SP/RP | 26 | 2009 |
| Still blocked by a solid Rays rotation. Could see significant time as a middle reliever. |
| 18 | Ryan Tucker | | SP/RP | 22 | 2009 |
| Short stint in the majors last season wasn't impressive. Could be moved to bullpen. |
| 19 | Brett Cecil | | SP | 22 | 2009 |
| A little more seasoning in AAA could mean a call up to the bigs in '09. |
| 20 | Jason Motte | | RP | 26 | 2009 |
| For a team looking for bullpen help, Motte's 110 Ks in 66.2 innings will help in '09. |
| 21 | David Hernandez | Baltimore Orioles | SP | 23 | 2009 |
| Huge strikeout numbers but can be wild at times. Baltimore will need him in '09. |
| 22 | Phil Coke | | RP | 26 | 2009 |
| Gave up one ER in 14.2 innings during his '08 debut. Could be a solid reliever next season. |
| 23 | Carlos Rosa | | RP | 24 | 2009 |
| Kansas City will move him to the bullpen. |
| 24 | Kevin Jepsen | Los Angeles Angels | RP | 24 | 2009 |
| Solid in his '08 major league debut. Could see a good chunk of time in the Angels bulllpen. |
| 25 | Casey Weathers | | RP | 23 | 2009 |
| Future Rockies closer looking to repeat solid 2008. |
| 26 | Brad Mills | Toronto Blue Jays | SP | 24 | 2010 |
| Great led Mills to AA last season. 1.95 ERA for the year with 159 Ks. |
| 27 | Rick Porcello | | SP | 20 | 2010 |
| Consistency will be key for this young hurler. Not a dazzling pitcher but will be solid. |
| 28 | Jason Berken | Baltimore Orioles | SP/RP | 25 | 2010 |
| Impressive 2008 campaign increases the chances of Berken joining the big league roster in '10. |
| 29 | Kevin Pucetas | | SP | 24 | 2010 |
| 25 wins and 6 losses over the last two seasons. Great ERA and K:BB ratio. |
| 30 | Matthew Buschmann | | SP | 25 | 2010 |
| Solid overall pitcher. Doesn't dazzle but can eat up innings. |
| 31 | Will Inman | San Diego Padres | SP | 22 | 2010 |
| Impressive strikeout numbers but must work on consistency to make an impact in the bigs. |
| 32 | Vincent Mazzaro | Oakland Athletics | SP/RP | 22 | 2010 |
| Solid '08 was a stark contrast to '07. If he can repeat his numbers look for his addition to the Oakland bullpen. |
| 33 | Jon Link | | RP | 25 | 2010 |
| Solid closer who could get a shot in late '09. 35 saves in '08. |
| 34 | Jake Arrieta | Baltimore Orioles | SP | 23 | 2010 |
| Another impressive Oriole. CAR pitcher of the year. Look for quick progression through the system. |
| 35 | Neftali Feliz | Texas Rangers | SP | 20 | 2010 |
| Finished the season in AA. His great stuff won't keep him in the minors much longer, |
| 36 | Ben Snyder | San Francisco Giants | SP | 23 | 2010 |
| Shaky AA debut after promotion last year. Needs to watch opponents AVG. |
| 37 | Jeremy Hellickson | Tampa Bay Rays | SP | 22 | 2010 |
| 162:20 K:BB ratio last season. Will be a nice compliment to David Price. |
| 38 | Jess Todd | St. Louis Cardinals | SP | 23 | 2010 |
| Went from A+ to AAA last season. Solid numbers overall. |
| 39 | Eduardo Morlan | Tampa Bay Rays | RP | 23 | 2010 |
| Solid relief pitching prospect. Tendency to give up hits but strikeouts are there. |
| 40 | Madison Bumgarner | San Francisco Giants | SP | 19 | 2011 |
| Big guy with 164:21 K:BB ratio. Named Class A starting pitcher of the year. |
| 41 | Dillon Gee | | SP | 23 | 2011 |
| Good K:BB ratio. Solid starter who could advance quicker than anticipated. |
| 42 | Aaron Poreda | Chicago White Sox | RP | 22 | 2011 |
| Big pitcher at 6'6”. Will be moved to the bullpen where he will make his name. |
| 43 | Andrew Carignan | Oakland Athletics | RP | 22 | 2011 |
| Low opponents AVG but must work on command. Decent K-rate. |
| 44 | Jon Kibler | Detroit Tigers | SP | 22 | 2011 |
| Unhittable in '08 with a .190 opponents AVG. |
| 45 | Jarrod Parker | | SP | 20 | 2011 |
| Impressive rookie season in A ball. Will move up quickly in Arizona's system. |
| 46 | Jeremy Jeffress | | SP | 21 | 2011 |
| Still developing but making significant progress. His strikeout numbers have always been there. |
| 47 | Phillippe Aumont | | SP | 20 | 2011 |
| Scouts say he is ace material. Will be on a strict pitch count in the minors. |
| 48 | Aneury Rodriguez | Colorado Rockies | SP | 21 | 2011 |
| Two complete-game shutouts last season. Keeps improving. |
| 49 | Tim Alderson | San Francisco Giants | SP | 20 | 2011 |
| Class A+ starting pitcher of the year. 13 wins and only allowed 4 HRs all season. |
| 50 | George Kontos | New York Yankees | SP/RP | 23 | 2011 |
| Solid starter who will move to the Yankees bullpen. |